How Stem Cells Enter the Central Nervous System via the Nasal Cavity
Researchers made a surprising discovery about the delivery of cells to the central nervous system (CNS). They found that intranasal administration was a noninvasive path that could become therapy for neurological diseases.
Scientists have published 40 more articles since 2009 on the usage of stem cells for neurological conditions. They used mesenchymal stem cells (MSCs) as well as neural stem cells (NSCs). They deliver cells into the nasal cavity that reach the CNS. They observed them in the vicinity of the olfactory bulb.
Researchers did not anticipate that the cells would enter the brain via the nasal cavity. The size and barriers there must be crossed and the norm with other treatments is different. These agents include small molecule drugs, proteins, viruses, and bacteria, as well as nanoparticles and microparticles.
Cells must cross the olfactory epithelium and the cribriform plate to reach the brain from the nasal cavity. There is not much evidence to understand how the cells make this journey.
More research is necessary to understand how cells cross the cribriform plate to enter the brain from the nose. This treatment can become more practical and efficient once this insight can be determined. It would be better to track the cells during delivery to know how and where they go. This study is focused on understanding this mechanism.