Functional reconstruction of nasal mucosal tissue
Tissue engineering and repaid of tissue damage is evolving with regenerative medicine. Researchers identified key cells as well as cell stroma that may aid healing.
Adipose-derived stem cells (ADSCs) are such cells. Experts consider their quality and in fact they bring many benefits. Indeed, it is possible to gain a vast amount of these cells. Besides, they are simple to detect and culture. Not only are they safe, it is also possible for them to grow quickly.
Empty nose syndrome (ENS) is an iatrogenic disorder usually detected when paradoxical nasal obstruction happens even though a patient may show a wide, patent nasal fossa. Physicians and others say ‘empty nose syndrome’ regarding symptoms is linked to tissue loss.
Moreover, radiographic findings of a paucity of normal anatomic structures within the nasal cavities is also evident. 20 % of patients will develop ENS after a procedure removing the inferior nasal concha.
Patients currently do not have any options for ENS. Patients discomfort or pain might not be reflected in objective measurements by doctors and may cause tension between patient and doctor. Hence, a new treatment is highly desirable for patients.
30 ENS patients in this study did not show infection or allergy after transplantation of ADSCs and fat particles into the areas of nasal damage. 28 patients improved symptoms. 2 patients gained better nasal cavity sensation with less dryness. However, excessive breathing continues to be a challenge.